Retracted: Down‐regulation of long noncoding RNA PVT 1 inhibits esophageal carcinoma cell migration and invasion and promotes cell apoptosis via micro RNA ‐145‐mediated inhibition of FSCN 1

Accumulating evidence has established that long noncoding RNA (lnc RNA ) plasmacytoma variant translocation 1 ( PVT 1) is a tumor regulator in many cancers. Here, we aimed to investigate the possible function of lnc RNA PVT 1 in esophageal carcinoma ( EC ) via targeting of micro RNA ‐145 (miR‐145). Initially, microarray‐based gene expression profiling of EC was employed to identify differentially expressed genes. Moreover, the expression of lnc RNA PVT 1 was examined and the cell line presenting with the highest level of lnc RNA PVT 1 expression was selected for subsequent experiments. We then proceeded to examine interaction among lnc RNA PVT 1, FSCN 1, and miR‐145. The effect of lnc RNA PVT 1 on viability, migration, invasion, apoptosis, and tumorigenesis of transfected cells was examined with gain‐of‐function and loss‐of‐function experiments. We observed that lnc RNA PVT 1 was robustly induced in EC . lnc RNA PVT 1 could bind to miR‐145 and regulate its expression, and FSCN 1 is a target gene of miR‐145. Overexpression of miR‐145 or silencing of lnc RNA PVT 1 was revealed to suppress cell viability, migration, and invasion abilities, while also stimulating cell apoptosis. Furthermore, our in vivo results showed that overexpression of miR‐145 or silencing of lnc RNA PVT 1 resulted in decreased tumor growth in nude mice. In conclusion, our research reveals that down‐regulation of lnc RNA PVT 1 could potentially promote expression of miR‐145 to repress cell migration and invasion, and promote cell apoptosis through the inhibition of FSCN 1. This highlights the potential of lnc RNA PVT 1 as a therapeutic target for EC treatment.