Open AccessAberrantly expressed PLOD 1 promotes cancer aggressiveness in bladder cancer: a potential prognostic marker and therapeutic target
Author(s) -
Yamada Yasutaka,
Kato Mayuko,
Arai Takayuki,
Sanada Hiroki,
Uchida Akifumi,
Misono Shunsuke,
Sakamoto Shinichi,
Komiya Akira,
Ichikawa Tomohiko,
Seki Naohiko
Publication year - 2019
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12532
Subject(s) - cancer research , biology , cancer , downregulation and upregulation , medicine , oncology , gene , biochemistry
Bladder cancer ( BC ) is the ninth most malignant tumor worldwide. Some BC patients will develop muscle‐invasive BC ( MIBC ), which has a 5‐year survival rate of approximately 60% due to metastasis. As such, there is an urgent need for novel therapeutic and diagnostic targets for MIBC . Analysis of novel antitumor micro RNA (mi RNA )‐mediated cancer networks is an effective strategy for exploring therapeutic targets and prognostic markers in cancers. Our previous mi RNA analysis revealed that miR‐140‐5p acts as an antitumor mi RNA in BC cells. Here, we investigated miR‐140‐5p regulation of BC molecular pathogenesis. Procollagen‐lysine, 2‐oxoglutarate 5‐dioxygenase 1 ( PLOD 1 ) was found to be directly regulated by miR‐140‐5p , and aberrant expression of PLOD 1 was observed in BC clinical specimens. High PLOD 1 expression was significantly associated with a poor prognosis (disease‐free survival: P = 0.0204; overall survival: P = 0.000174). Multivariate analysis showed PLOD 1 expression to be an independent prognostic factor in BC patients (hazard ratio = 1.51, P = 0.0099). Furthermore, downregulation of PLOD 1 by si RNA s and a specific inhibitor significantly decreased BC cell aggressiveness. Aberrant expression of PLOD 1 was closely associated with BC pathogenesis. In summary, the present study showed that PLOD 1 may be a potential prognostic marker and therapeutic target for BC .