Open AccessTranslational cancer research – a coherent cancer research continuum
Author(s) -
Ringborg Ulrik
Publication year - 2019
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12450
Subject(s) - translational research , cancer , medicine , cancer prevention , clinical research , medical research , cancer medicine , precision medicine , basic research , alternative medicine , computer science , pathology , library science
The main components of the cancer research continuum are basic/preclinical research, early and late clinical research and, after the adoption of an innovation by the healthcare or health organisations, outcomes research. Translational cancer research, defined as a coherent cancer research continuum, is mandatory to address the increasing burden of cancer effectively. The growing cancer problem can only be significantly modified by concerted action involving prevention to decrease incidence, early detection and treatment to increase the cure rate, and personalised/precision cancer medicine to adapt early detection and treatment to the biology of a tumour with the aim of increasing the cure rate, prolonging survival and improving health‐related quality of life. By definition, translational cancer research for therapeutics has a focus on patients’ needs and for prevention for individuals at‐risk. Consequently, to increase the effectiveness of translational research, the different components of the cancer research continuum need to be better connected to the fundamental aim of a mission‐oriented approach to cancer (Celis and Pavalkis, [Celis JE, 2017]).