Rapid proteomic analysis for solid tumors reveals  LSD 1 as a drug target in an end‐stage cancer patient | Zendy

Doll Sophia | Zendy; Kriegmair Maximilian C. | Zendy; Santos Alberto | Zendy; Wierer Michael | Zendy; Coscia Fabian | Zendy; Neil Helen Michele | Zendy; Porubsky Stefan | Zendy; Geyer Philipp E. | Zendy; Mund Andreas | Zendy; Nuhn Philipp | Zendy; Mann Matthias | Zendy

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Rapid proteomic analysis for solid tumors reveals LSD 1 as a drug target in an end‐stage cancer patient

Author(s) -

Doll Sophia,

Kriegmair Maximilian C.,

Santos Alberto,

Wierer Michael,

Coscia Fabian,

Neil Helen Michele,

Porubsky Stefan,

Geyer Philipp E.,

Mund Andreas,

Nuhn Philipp,

Mann Matthias

Publication year - 2018

Publication title -

molecular oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.332

H-Index - 88

eISSN - 1878-0261

pISSN - 1574-7891

DOI - 10.1002/1878-0261.12326

Subject(s) - drug , solid tumor , cancer , stage (stratigraphy) , chemistry , cancer research , biology , pharmacology , genetics , paleontology

Recent advances in mass spectrometry ( MS )‐based technologies are now set to transform translational cancer proteomics from an idea to a practice. Here, we present a robust proteomic workflow for the analysis of clinically relevant human cancer tissues that allows quantitation of thousands of tumor proteins in several hours of measuring time and a total turnaround of a few days. We applied it to a chemorefractory metastatic case of the extremely rare urachal carcinoma. Quantitative comparison of lung metastases and surrounding tissue revealed several significantly upregulated proteins, among them lysine‐specific histone demethylase 1 ( LSD 1/ KDM 1A). LSD 1 is an epigenetic regulator and the target of active development efforts in oncology. Thus, clinical cancer proteomics can rapidly and efficiently identify actionable therapeutic options. While currently described for a single case study, we envision that it can be applied broadly to other patients in a similar condition.

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