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How circadian clocks keep time: the discovery of slowness
Author(s) -
Partch Carrie,
Brunner Michael
Publication year - 2022
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.14432
Subject(s) - slowness , circadian rhythm , circadian clock , molecular clock , hyperphosphorylation , biology , biological clock , neuroscience , microbiology and biotechnology , evolutionary biology , phosphorylation , physics , genetics , gene , phylogenetics , quantum mechanics
Circadian clocks are molecular timers that measure 24‐hour periods through a series of slow but precise biochemical processes. While circadian clocks of cyanobacteria are driven by interactions and ordered phosphorylation of highly structured protein assemblies, timekeeping by circadian clocks of eukaryotes involves slow progressive hyperphosphorylation of a large number of redundant sites in intrinsically disordered regions of clock proteins.