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Interorgan crosstalk in pancreatic islet function and pathology
Author(s) -
Evans Ronald M.,
Wei Zong
Publication year - 2022
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.14282
Subject(s) - crosstalk , islet , pancreas , endocrine system , immune system , pancreatic islets , biology , function (biology) , enteroendocrine cell , insulin , endocrinology , medicine , neuroscience , bioinformatics , immunology , microbiology and biotechnology , hormone , physics , optics
Pancreatic β cells secrete insulin in response to glucose, a process that is regulated at multiple levels, including a network of input signals from other organ systems. Impaired islet function contributes to the pathogenesis of type 2 diabetes mellitus (T2DM), and targeting inter‐organ communications, such as GLP‐1 signalling, to enhance β‐cell function has been proven to be a successful therapeutic strategy in the last decade. In this review, we will discuss recent advances in inter‐organ communication from the metabolic, immune and neural system to pancreatic islets, their biological implication in normal pancreas endocrine function and their role in the (mal)adaptive responses of islet to nutrition‐induced stress.