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The SLIM1 transcription factor is required for arsenic resistance in Arabidopsis thaliana
Author(s) -
Jobe Timothy O.,
Yu Qi,
Hauser Felix,
Xie Qingqing,
Meng Yuan,
Maassen Tim,
Kopriva Stanislav,
Schroeder Julian I.
Publication year - 2021
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.14096
Subject(s) - arsenic , transcription factor , mutant , biology , arabidopsis thaliana , transcriptome , arsenic toxicity , gene , microbiology and biotechnology , genetics , gene expression , chemistry , organic chemistry
The transcriptional regulators of arsenic‐induced gene expression remain largely unknown. Sulfur assimilation is tightly linked with arsenic detoxification. Here, we report that mutant alleles in the SLIM1 transcription factor are substantially more sensitive to arsenic than cadmium. Arsenic treatment caused high levels of oxidative stress in the slim1 mutants, and slim1 alleles were impaired in both thiol accumulation and sulfate accumulation. We further found enhanced arsenic accumulation in roots of slim1 mutants. Transcriptome analyses indicate an important role for SLIM1 in arsenic‐induced tolerance mechanisms. The present study identifies the SLIM1 transcription factor as an essential component in arsenic tolerance and arsenic‐induced gene expression. Our results suggest that the severe arsenic sensitivity of the slim1 mutants is caused by altered redox status.