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An immunomodulatory role for the Mycobacterium tuberculosis Acr protein in the formation of the tuberculous granuloma
Author(s) -
Healy Eamonn F.,
Goering Lisa M.,
Hauser Charles R.,
King Peter J.
Publication year - 2021
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.13998
Subject(s) - mycobacterium tuberculosis , chemokine , proteases , immune system , innate immune system , immunology , microbiology and biotechnology , mycobacterium , granuloma , tuberculosis , cxcl16 , heat shock protein , biology , cxcl10 , medicine , pathology , gene , biochemistry , enzyme
The tuberculous granuloma is a compact aggregate of dormant bacteria encapsulated by host macrophages. It is commonly regarded as a product of the host defense designed to isolate infectious mycobacteria. This work demonstrates that exposure of macrophages to the Mtb heat‐shock protein Acr leads to overproduction of the chemokine CXCL16, allowing the mycobacterium to exploit the innate immune response. This induction of chemokine expression is hypothesized to occur through activation of ADAM proteases, providing an immunomodulatory role for Mtb Acr in the formation of the granuloma.