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A twist in the ABC: regulation of ABC transporter trafficking and transport by FK506‐binding proteins
Author(s) -
Geisler Markus,
Hegedűs Tamás
Publication year - 2020
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.13983
Subject(s) - atp binding cassette transporter , fkbp , biogenesis , biology , ubiquitin , prolyl isomerase , transporter , peptidylprolyl isomerase , phosphorylation , microbiology and biotechnology , transport protein , pin1 , biochemistry , isomerase , gene
Post‐transcriptional regulation of ATP‐binding cassette (ABC) proteins has been so far shown to encompass protein phosphorylation, maturation, and ubiquitination. Yet, recent accumulating evidence implicates FK506‐binding proteins (FKBPs), a type of peptidylprolyl cis–trans isomerase (PPIase) proteins, in ABC transporter regulation. In this perspective article, we summarize current knowledge on ABC transporter regulation by FKBPs, which seems to be conserved over kingdoms and ABC subfamilies. We uncover striking functional similarities but also differences between regulatory FKBP‐ABC modules in plants and mammals. We dissect a PPIase‐ and HSP90‐dependent and independent impact of FKBPs on ABC biogenesis and transport activity. We propose and discuss a putative new mode of transient ABC transporter regulation by cis–trans isomerization of X‐prolyl bonds.