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Structural and functional diversity calls for a new classification of ABC transporters
Author(s) -
Thomas Christoph,
Aller Stephen G.,
Beis Konstantinos,
Carpenter Elisabeth P.,
Chang Geoffrey,
Chen Lei,
Dassa Elie,
Dean Michael,
Duong Van Hoa Franck,
Ekiert Damian,
Ford Robert,
Gaudet Rachelle,
Gong Xin,
Holland I. Barry,
Huang Yihua,
Kahne Daniel K.,
Kato Hiroaki,
Koronakis Vassilis,
Koth Christopher M.,
Lee Youngsook,
Lewinson Oded,
Lill Roland,
Martinoia Enrico,
Murakami Satoshi,
Pinkett Heather W.,
Poolman Bert,
Rosenbaum Daniel,
Sarkadi Balazs,
Schmitt Lutz,
Schneider Erwin,
Shi Yigong,
Shyng ShowLing,
Slotboom Dirk J.,
Tajkhorshid Emad,
Tieleman D. Peter,
Ueda Kazumitsu,
Váradi András,
Wen PoChao,
Yan Nieng,
Zhang Peng,
Zheng Hongjin,
Zimmer Jochen,
Tampé Robert
Publication year - 2020
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.13935
Subject(s) - atp binding cassette transporter , computational biology , biology , transporter , transmembrane domain , homology (biology) , transmembrane protein , solute carrier family , superfamily , homology modeling , sequence homology , genetics , biochemistry , peptide sequence , gene , enzyme , receptor
Members of the ATP‐binding cassette (ABC) transporter superfamily translocate a broad spectrum of chemically diverse substrates. While their eponymous ATP‐binding cassette in the nucleotide‐binding domains (NBDs) is highly conserved, their transmembrane domains (TMDs) forming the translocation pathway exhibit distinct folds and topologies, suggesting that during evolution the ancient motor domains were combined with different transmembrane mechanical systems to orchestrate a variety of cellular processes. In recent years, it has become increasingly evident that the distinct TMD folds are best suited to categorize the multitude of ABC transporters. We therefore propose a new ABC transporter classification that is based on structural homology in the TMDs.