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TC‐E 5003, a protein methyltransferase 1 inhibitor, activates the PKA‐dependent thermogenic pathway in primary murine and human subcutaneous adipocytes
Author(s) -
Park MinJung,
Liao Jiling,
Kim Dongil
Publication year - 2020
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.13900
Subject(s) - thermogenesis , lipolysis , medicine , endocrinology , adipocyte , receptor , chemistry , protein kinase a , signal transduction , adipose tissue , biology , kinase , biochemistry
TC‐E 5003 increases the expression of UCP1 in primary iWAT cells. TC‐E 5003 activates the downstream molecules of PKA signaling. Thermogenic effects of TC‐E 5003 are PRMT1‐ and β‐adrenergic receptor‐independent. TC‐E 5003 potently works in human SQ adipocytes isolated from multiple donors.