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Coronin 2B regulates dendrite outgrowth by modulating actin dynamics
Author(s) -
Chen Yuewen,
Xu Jinying,
Zhang Yulin,
Ma Shuangshuang,
Yi Wanying,
Liu Saijuan,
Yu Xiaojun,
Wang Jiali,
Chen Yu
Publication year - 2020
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.13886
Subject(s) - microbiology and biotechnology , actin , actin remodeling of neurons , cytoskeleton , dendrite (mathematics) , neurite , actin remodeling , actin cytoskeleton , actin binding protein , biology , chemistry , biophysics , biochemistry , cell , geometry , mathematics , in vitro
Cytoskeletal remodeling is indispensable for the development and maintenance of neuronal structures and functions. However, the molecular machinery that controls the balance between actin polymerization and depolymerization during these processes is incompletely understood. Here, we report that coronin 2B, a conserved actin‐binding protein, is concentrated at the tips of developing dendrites and that knockdown of coronin 2B inhibits the growth of dendrites. Importantly, coronin 2B interacts with actin and reduces the F‐actin/G‐actin ratio. Furthermore, the coiled‐coil domain of coronin 2B is required for its oligomerization, thus confining coronin 2B to neurite tips. Our findings collectively suggest that coronin 2B is important for promoting dendrite outgrowth by limiting the speed of actin polymerization at growth cones.