Premium
The cytochrome bc 1 complex as an antipathogenic target
Author(s) -
Fisher Nicholas,
Meunier Brigitte,
Biagini Giancarlo A.
Publication year - 2020
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.13868
Subject(s) - coenzyme q – cytochrome c reductase , cytochrome , mode of action , cytochrome c , plasmodium falciparum , cytochrome b , mechanism of action , biology , cytochrome p450 , biochemistry , respiratory chain , mitochondrion , malaria , chemistry , microbiology and biotechnology , enzyme , mitochondrial dna , gene , immunology , in vitro
The cytochrome bc 1 complex is a key component of the mitochondrial respiratory chains of many eukaryotic microorganisms that are pathogenic for plants or humans, such as fungi responsible for crop diseases and Plasmodium falciparum , which causes human malaria. Cytochrome bc 1 is an enzyme that contains two (ubi)quinone/quinol‐binding sites, which can be exploited for the development of fungicidal and chemotherapeutic agents. Here, we review recent progress in determination of the structure and mechanism of action of cytochrome bc 1 , and the associated development of antimicrobial agents (and associated resistance mechanisms) targeting its activity.