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Front Cover
Publication year - 2021
Publication title -
febs letters
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.13818
Subject(s) - cover (algebra) , front cover , substrate (aquarium) , computer science , cytidine deaminase , dna , chemistry , computational biology , biology , biochemistry , engineering , mechanical engineering , ecology
Cover illustration Structurally inherent self‐regulation of AID. The top bottleneck represents substrate selection wherein the vast majority of AID complexes with ssDNA or DNA/RNA are catalytically non‐productive and the minor proportion of substrates that fit into the ssDNA or RNA binding grooves are recognized by a plastic combination of two or three of the 5 substrate binding grooves. The second bottleneck is that even after the formation of the rare AID:substrate complexes that position a dC proximal to the catalytic pocket, AID’s catalytic pocket has a higher probability of being closed, a phenomenon termed the “Schrödinger’s CATalytic pocket. The cover image refers to the article “Structural plasticity of substrate selection by activation‐induced cytidine deaminase as a regulator of its genome‐wide mutagenic activity” by J. King and M. Larijani (pp. 3–13).