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Staphylococci evade the innate immune response by disarming neutrophils and forming biofilms
Author(s) -
Vor Lisanne,
Rooijakkers Suzan H. M.,
Strijp Jos A. G.
Publication year - 2020
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.13767
Subject(s) - innate immune system , immune system , staphylococcus aureus , immunology , microbiology and biotechnology , staphylococcus epidermidis , biology , evasion (ethics) , staphylococcal infections , pathogen , complement system , bacteria , genetics
Staphylococcus aureus and Staphylococcus epidermidis can cause many types of infections, ranging from skin infections to implant‐associated infections. The primary innate immune response against bacterial infections involves complement activation, recruitment of phagocytes (most importantly neutrophils), and subsequent killing of the pathogen. However, staphylococci are not innocent bystanders; they actively obstruct this immune attack. To do that, S. aureus secretes several immune‐evasion proteins to resist attack by the innate immune system. Furthermore, S. aureus and S. epidermidis are known for their ability to form biofilms on implanted medical devices and host tissues, which provides another important immune‐evasion mechanism. Understanding these different strategies to resist immune attack will help to develop novel therapies against staphylococcal infections.