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Murine adenoviruses: tools for studying adenovirus pathogenesis in a natural host
Author(s) -
Hemmi Silvio,
Spindler Katherine R.
Publication year - 2019
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.13699
Subject(s) - biology , virology , tissue tropism , tropism , host (biology) , laboratory mouse , virus , viral pathogenesis , immune system , pathogenesis , genetics , gene , viral replication , immunology
Small laboratory animals are powerful models for investigating in vivo viral pathogenesis of a number of viruses. For adenoviruses (AdVs), however, species‐specificity poses limitations to studying human adenoviruses (HAdVs) in mice and other small laboratory animals. Thus, this review covers work on naturally occurring mouse AdVs, primarily mouse adenovirus type 1 (MAdV‐1), a member of the species Murine mastadenovirus A . Molecular genetics, virus life cycle, cell and tissue tropism, interactions with the host immune response, persistence, and host genetics of susceptibility are described. A brief discussion of MAdV‐2 (member of species Murine mastadenovirus B ) and MAdV‐3 (member of species Murine mastadenovirus C ) is included. We report the use of MAdVs in the development of vectors and vaccines.