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Stress‐specific aggregation of proteins in the amyloid bodies
Author(s) -
Marijan Dane,
Tse Ronnie,
Elliott Keenan,
Chandhok Sahil,
Luo Monica,
Lacroix Emma,
Audas Timothy E.
Publication year - 2019
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.13597
Subject(s) - protein aggregation , chemistry , organelle , amyloid (mycology) , microbiology and biotechnology , biophysics , amyloid fibril , amyloid β , biochemistry , biology , medicine , pathology , inorganic chemistry , disease
Physiological amyloid aggregation occurs within the nuclei of stress‐treated cells. These structures, termed Amyloid bodies (A‐bodies), assemble through the rapid accumulation of proteins into dense membrane‐less organelles, which possess the same biophysical properties as plaques observed in many amyloid‐based diseases. Here, we demonstrate that A‐body proteomic compositions vary significantly between stimuli, as constituent proteins can be sequestered by one or more stressors. Stimulus exposure alone was insufficient to induce aggregation, demonstrating that this pathway is not regulated solely by stress‐induced conformational changes of the A‐body targets. We propose that different environmental conditions induce the formation of A‐body subtypes containing distinct protein residents. This selective immobilization of proteins may have evolved as a finely tuned mechanism for surviving divergent stressors.