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Angiopoietin‐Tie signaling in kidney diseases: an updated review
Author(s) -
He FangFang,
Zhang Di,
Chen Qing,
Zhao Yi,
Wu Liang,
Li ZhenQiong,
Zhang Chun,
Jiang ZhaoHua,
Wang YuMei
Publication year - 2019
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.13568
Subject(s) - angiogenesis , kidney , diabetic nephropathy , signal transduction , cancer research , medicine , angiopoietin , renal cell carcinoma , kidney disease , kidney cancer , biology , bioinformatics , immunology , pathology , vascular endothelial growth factor , microbiology and biotechnology , vegf receptors
Angiopoietins (Angs) are a family of vascular growth factors that share multiple cellular functions related to cell survival, proliferation, and migration. Angs play physiological and pathological roles through the Tie tyrosine kinase receptors. The Ang‐Tie signaling pathway participates in the developmental and tumor‐induced angiogenesis and is also involved in many disease settings, such as vascular diseases, systemic inflammation, and cancers. Since Angs are widely expressed in the kidney, an enormous amount of research focuses on their roles in the kidney. In this review, we describe the biological functions of the Ang‐Tie signaling pathway and summarize their roles in kidney development and maturation, acute and chronic kidney diseases, diabetic nephropathy, lupus nephropathy, hemolytic uremic syndrome, end‐stage renal diseases, and renal cell carcinoma. Understanding the molecular mechanisms of Ang‐Tie signaling may reveal potential therapeutic targets for preventing or alleviating kidney diseases.