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Bromhexine elevates REP2 expression to stimulate secretion from human primary conjunctiva fornix epithelial cells
Author(s) -
Wang Ling,
Yu Li,
Li Ning,
Wang Yuan,
Yang Meina,
Peng Yun,
Guo Hui,
Ye Lin
Publication year - 2020
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.13560
Subject(s) - fornix , secretion , downregulation and upregulation , medicine , conjunctiva , gene expression , endocrinology , pharmacology , gene , immunology , biology , biochemistry , hippocampus
Bromhexine was reported to relieve the symptoms of Sjogren Syndrome at an early stage. However, the underlying mechanism remains unclear. Here, we administered bromhexine at low doses in human primary conjunctival fornix epithelial cells, and found it stimulated MUC5AC secretion and lipid droplet production. Expression of the metabolism‐related gene CHML was also upregulated by bromhexine treatment, and REP2, the protein produced by the CHML gene, was induced. These results suggest that bromhexine is a potential candidate eye drop drug for the treatment of multiple types of dry eye disease, not only limited to the treatment of dry eyes in Sjogren Syndrome.