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Lipid‐dependent coupling of secretory cargo sorting and trafficking at the trans‐Golgi network
Author(s) -
von Blume Julia,
Hausser Angelika
Publication year - 2019
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.13552
Subject(s) - golgi apparatus , microbiology and biotechnology , diacylglycerol kinase , sphingolipid , secretory pathway , chemistry , ceramide , lipid signaling , sorting , biology , biochemistry , endoplasmic reticulum , signal transduction , computer science , enzyme , protein kinase c , programming language , apoptosis
In eukaryotic cells, the trans‐Golgi network ( TGN ) serves as a platform for secretory cargo sorting and trafficking. In recent years, it has become evident that a complex network of lipid–lipid and lipid–protein interactions contributes to these key functions. This review addresses the role of lipids at the TGN with a particular emphasis on sphingolipids and diacylglycerol. We further highlight how these lipids couple secretory cargo sorting and trafficking for spatiotemporal coordination of protein transport to the plasma membrane.