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UCP 2 gene polymorphisms in obesity and diabetes, and the role of UCP 2 in cancer
Author(s) -
Li Jinran,
Jiang Rihua,
Cong Xianling,
Zhao Yunfeng
Publication year - 2019
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.13546
Subject(s) - mitochondrion , biology , cancer , cancer cell , inner mitochondrial membrane , diabetes mellitus , insulin resistance , oxidative stress , endocrinology , medicine , microbiology and biotechnology , genetics
Mitochondria are the primary sites for ATP synthesis and free radical generation in organisms. Abnormal mitochondrial metabolism contributes to many diseases, including obesity, diabetes and cancer. UCP 2 is an ion/anion transporter located in mitochondrial inner membrane, and has a crucial role in regulating oxidative stress, cellular metabolism, cell proliferation and cell death. Polymorphisms of the UCP 2 gene have been associated with diabetes and obesity because UCP 2 is involved in energy expenditure and insulin secretion. Moreover, UCP 2 gene expression is often amplified in cancers, and increased UCP 2 expression contributes to cancer growth, cancer metabolism, anti‐apoptosis and drug resistance. The present review summarizes the latest findings of UCP 2 with respect to obesity, diabetes and cancer.