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Compositional and functional features of the female premenopausal and postmenopausal gut microbiota
Author(s) -
Zhao Hui,
Chen Juanjuan,
Li Xiaoping,
Sun Qiang,
Qin Panpan,
Wang Qi
Publication year - 2019
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.13527
Subject(s) - gut flora , physiology , postmenopausal women , roseburia , firmicutes , estrogen , menopause , microbiome , medicine , bacteroidetes , biology , endocrinology , bioinformatics , lactobacillus , immunology , bacteria , 16s ribosomal rna , genetics
Endogenous estrogen deficiency accelerates many diseases in postmenopausal women, and gut microbes contribute to estrogen level modulation. However, the compositional alterations and influences of the gut microbiota in postmenopausal women remain uncertain. A metagenome‐wide association study was performed to compare the gut microbiota of 24 premenopausal and 24 postmenopausal women. Firmicutes and Roseburia spp . are depleted, while Bacteroidetes and the toluene‐producing genus Tolumonas are overrepresented in fecal samples from postmenopausal women. The pentose phosphate pathway is enriched in premenopausal women. Homocysteine synthesis‐related processes are enriched in postmenopausal women. The gut microbiomes of premenopausal and postmenopausal women differ and produce different metabolites. The gut microbiome may be a therapeutic target to reduce risks and improve the quality of life in postmenopausal women.