Premium
Derepression of matrix metalloproteinase gene transcription and an emphysema‐like phenotype in transcription factor Zbtb7c knockout mouse lungs
Author(s) -
Jeon BuNam,
Song JiYang,
Huh Jin Won,
Yang WooIck,
Hur ManWook
Publication year - 2019
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.13501
Subject(s) - pathogenesis , matrix metalloproteinase , knockout mouse , phenotype , gene , gene expression , biology , transcription factor , pathology , downregulation and upregulation , microbiology and biotechnology , immunology , medicine , genetics
Dysregulated matrix metalloproteinase ( MMP ) gene expression is a major cause of the degradation of lung tissue that is integral to emphysema pathogenesis. Cigarette smoking (CS) increases MMP gene expression, a major contributor to emphysema development. We previously reported that Zbtb7c is a transcriptional repressor of several Mmp genes ( Mmps‐ 8, ‐10, ‐13, and ‐16). Here, we show that Zbtb7c knockout mice have mild emphysema‐like phenotypes, including alveolar wall destruction, enlarged alveoli, and upregulated Mmp genes. Alveolar size and Mmp gene expression in Zbtb7c −/− mouse lungs are increased more severely upon exposure to CS, compared to those of Zbtb7c +/+ mouse lungs. These observations suggest that Zbtb7c degradation or absence may contribute to the pathogenesis of emphysema.