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Oncostatin M expression in the mouse uterus during early pregnancy promotes embryo implantation and decidualization
Author(s) -
Fu Tao,
Zheng HongTao,
Zhang HaiYi,
Chen ZiCong,
Li Bo,
Yang ZengMing
Publication year - 2019
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.13468
Subject(s) - decidualization , oncostatin m , embryo , decidual cells , andrology , decidua , uterus , medicine , biology , endocrinology , pregnancy , microbiology and biotechnology , chemistry , interleukin 6 , cytokine , fetus , placenta , genetics
Oncostatin M (OSM) is a member of the interleukin‐6 (IL‐6) family, which functions in embryo implantation and decidualization. The expression, function and regulation of Osm in mouse uteri during early pregnancy remain unknown. We show that Osm is mainly expressed in the uterine epithelium from days 1 to 4 of pregnancy and in decidual cells on day 5 of pregnancy. Osm promotes the attachment of Osm‐soaked blue beads, which mimic blastocysts, to a pseudopregnant mouse uterus. Prostaglandin E2 (PGE 2 )‐induced Osm in mouse uterine epithelial cells upregulates the levels of Il‐33 expression and phosphorylates Stat3. In vitro decidualization is significantly promoted by Osm. Our results indicate that PGE 2 ‐induced Osm may mediate embryo implantation through Il‐33 and participate in decidualization via the Stat3‐Egr1 pathway.