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Ribonucleotides in mitochondrial DNA
Author(s) -
Wanrooij Paulina H.,
Chabes Andrei
Publication year - 2019
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.13440
Subject(s) - mitochondrial dna , dna replication , genome instability , biology , genome , nuclear dna , dna , genetics , mitochondrion , dna damage , microbiology and biotechnology , gene
The incorporation of ribonucleotides ( rNMP s) into DNA during genome replication has gained substantial attention in recent years and has been shown to be a significant source of genomic instability. Studies in yeast and mammals have shown that the two genomes, the nuclear DNA ( nDNA ) and the mitochondrial DNA (mt DNA ), differ with regard to their rNMP content. This is largely due to differences in rNMP repair – whereas rNMP s are efficiently removed from the nuclear genome, mitochondria lack robust mechanisms for removal of single rNMP s incorporated during DNA replication. In this minireview, we describe the processes that determine the frequency of rNMP s in the mitochondrial genome and summarise recent findings regarding the effect of incorporated rNMP s on mt DNA stability and function.