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Regulatory T cells sense effector T‐cell activation through synchronized JunB expression
Author(s) -
Wu Jingxia,
Ma Sicong,
HotzWagenblatt Agnes,
Angel Peter,
Mohr Kerstin,
Schlimbach Tilo,
Schmitt Michael,
Cui Guoliang
Publication year - 2019
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.13393
Subject(s) - junb , transcription factor , effector , immune system , biology , t cell , immunology , t cell receptor , autoimmunity , cancer research , inflammation , microbiology and biotechnology , gene , genetics
To maintain immune tolerance, effector T‐cell (Teff) responses must be checked by the regulatory T cells (Tregs) in time. It remains incompletely understood how Tregs sense real‐time Teff activation. Here, we report that the AP ‐1 transcription factor JunB, which is induced in Teffs upon T‐cell receptor ( TCR ) activation, is also increased in Tregs by TCR stimuli. Treg‐specific deletion of Junb impairs Treg identity, causes uncontrolled inflammatory cytokine production by Teffs and leads to the T‐box transcription factor T‐bet‐dependent spontaneous inflammation. Furthermore, JunB deficiency in Tregs unleashes antitumor Teff responses in a mouse model of melanoma. We conclude that JunB alarms Tregs of the emerging Teff activation and synchronizes immune regulation with the immune reaction in autoimmunity and cancer.