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miR‐134 inhibits osteosarcoma cell invasion and metastasis through targeting MMP 1 and MMP 3 in vitro and in vivo
Author(s) -
Chen Chenglong,
Zhang Long,
Jiao Yurui,
Zhou Yi,
Ge Qiaofeng,
Li Pengcui,
Sun Xiaojuan,
Lv Zhi
Publication year - 2019
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.13387
Subject(s) - osteosarcoma , mmp3 , cancer research , metastasis , angiogenesis , matrix metalloproteinase , in vitro , in vivo , cell migration , chemistry , biology , medicine , cancer , gene expression , gene , biochemistry , microbiology and biotechnology
miR‐134 has been shown to be associated with angiogenesis and the progression of osteosarcoma. This study further assessed the effects of miR‐134 expression on osteosarcoma cell migration, invasion, and metastasis in vitro and in a nude mouse xenograft model, exploring the underlying molecular events. Luciferase reporter assays revealed that miR‐134 directly targets the 3′‐ UTR s of MMP 1 and MMP 3 to reduce their expression in osteosarcoma cells. In conclusion, overexpression of miR‐134 suppresses osteosarcoma cell invasion and metastasis through the inhibition of MMP 1 and MMP 3 expression. We propose miR‐134 as an attractive novel therapeutic target for the treatment of osteosarcoma.