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Glucocorticoid receptor suppresses gene expression of Rev‐erbα (Nr1d1) through interaction with the CLOCK complex
Author(s) -
Murayama Yuki,
Yahagi Naoya,
Takeuchi Yoshinori,
Aita Yuichi,
Mehrazad Saber Zahra,
Wada Nobuhiro,
Li EnXu,
Piao Xianying,
Sawada Yoshikazu,
Shikama Akito,
Masuda Yukari,
NishiTatsumi Makiko,
Kubota Midori,
Izumida Yoshihiko,
Miyamoto Takafumi,
Sekiya Motohiro,
Matsuzaka Takashi,
Nakagawa Yoshimi,
Sugano Yoko,
Iwasaki Hitoshi,
Kobayashi Kazuto,
Yatoh Shigeru,
Suzuki Hiroaki,
Yagyu Hiroaki,
Kawakami Yasushi,
Shimano Hitoshi
Publication year - 2019
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.13328
Subject(s) - glucocorticoid receptor , chemistry , gene expression , microbiology and biotechnology , receptor , glucocorticoid , gene , biology , biochemistry , endocrinology
Glucocorticoids have various medical uses but are accompanied by side effects. The glucocorticoid receptor ( GR ) has been reported to regulate the clock genes, but the underlying mechanisms are incompletely understood. In this study, we focused on the suppressive effect of the GR on the expression of Rev‐erbα (Nr1d1), an important component of the clock regulatory circuits. Here we show that the GR suppresses Rev‐erbα expression via the formation of a complex with CLOCK and BMAL 1, which binds to the E‐boxes in the Nr1d1 promoter. In this GR ‐ CLOCK ‐ BMAL 1 complex, the GR does not directly bind to DNA , which is referred to as tethering. These findings provide new insights into the role of the GR in the control of circadian rhythm.