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Metabolite systems profiling identifies exploitable weaknesses in retinoblastoma
Author(s) -
Sahoo Swagatika,
Ravi Kumar Ranjith Kumar,
Nicolay Brandon,
Mohite Omkar,
Sivaraman Karthikeyan,
Khetan Vikas,
Rishi Pukhraj,
Ganesan Suganeswari,
Subramanyan Krishnakumar,
Raman Karthik,
Miles Wayne,
Elchuri Sailaja V.
Publication year - 2019
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.13294
Subject(s) - retinoblastoma , enucleation , computational biology , in vitro , biology , retinal , cancer research , biochemistry , genetics , gene
Retinoblastoma (RB) is a childhood eye cancer. Currently, chemotherapy, local therapy, and enucleation are the main ways in which these tumors are managed. The present work is the first study that uses constraint‐based reconstruction and analysis approaches to identify and explain RB‐specific survival strategies, which are RB tumor specific. Importantly, our model‐specific secretion profile is also found in RB1‐depleted human retinal cells in vitro and suggests that novel biomarkers involved in lipid metabolism may be important. Finally, RB‐specific synthetic lethals have been predicted as lipid and nucleoside transport proteins that can aid in novel drug target development.