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Disproportionate feedback interactions govern cell‐type specific proliferation in mammalian cells
Author(s) -
Sengupta Dola,
Kompella Vijay P. S.,
Kar Sandip
Publication year - 2018
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.13241
Subject(s) - cell growth , negative feedback , positive feedback , transition (genetics) , microbiology and biotechnology , cell type , cell , biology , dynamics (music) , genetics , physics , gene , quantum mechanics , voltage , electrical engineering , engineering , acoustics
In mammalian cells, the decision to maintain quiescence over proliferation commitment during G 1 ‐S transition depends on more than one intertwined feedback interaction and is highly cell‐type dependent. However, the precise role played by these individual feedback regulations in organizing such diverse proliferation dynamics is still poorly understood. Herein, we propose a predictive mathematical model of G 1 ‐S transition in mammalian cells that reconciles distinct single‐cell experimental observations in a cell‐type specific manner. The model analysis reveals that the feedback motifs responsible for the G 1 ‐S transition act in a disparate fashion to organize the cell‐type specific proliferation response. Importantly, the proposed model can be effectively tuned to gain insights into the proliferation commitment of diverse mammalian cell types and can find wide applicability.