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Biological functions, regulatory mechanisms, and disease relevance of RNA localization pathways
Author(s) -
Bovaird Samantha,
Patel Dhara,
Padilla JuanCarlos Alberto,
Lécuyer Eric
Publication year - 2018
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.13228
Subject(s) - relevance (law) , computational biology , rna , biological pathway , human disease , biology , chemistry , genetics , gene expression , gene , political science , law
The asymmetric subcellular distribution of RNA molecules from their sites of transcription to specific compartments of the cell is an important aspect of post‐transcriptional gene regulation. This involves the interplay of intrinsic cis‐ regulatory elements within the RNA molecules with trans‐ acting RNA‐binding proteins and associated factors. Together, these interactions dictate the intracellular localization route of RNAs, whose downstream impacts have wide‐ranging implications in cellular physiology. In this review, we examine the mechanisms underlying RNA localization and discuss their biological significance. We also review the growing body of evidence pointing to aberrant RNA localization pathways in the development and progression of diseases.