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The signal metabolite trehalose‐6‐phosphate inhibits the sucrolytic activity of sucrose synthase from developing castor beans
Author(s) -
Fedosejevs Eric T.,
Feil Regina,
Lunn John E.,
Plaxton William C.
Publication year - 2018
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.13197
Subject(s) - sucrose , sucrose phosphate synthase , biochemistry , trehalose , metabolite , regulator , atp synthase , chemistry , enzyme , invertase , isozyme , phosphate , sucrose synthase , gene
In plants, trehalose 6‐phosphate (T6P) is a key signaling metabolite that functions as both a signal and negative feedback regulator of sucrose levels. The mode of action by which T6P senses and regulates sucrose is not fully understood. Here, we demonstrate that the sucrolytic activity of RcSUS1, the dominant sucrose synthase isozyme expressed in developing castor beans, is allosterically inhibited by T6P. The feedback inhibition of SUS by T6P may contribute to the control of sink strength and sucrolytic flux in heterotrophic plant tissues.