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Noncanonical functions of micro RNA pathway enzymes – Drosha, DGCR 8, Dicer and Ago proteins
Author(s) -
Pong Sheng K.,
Gullerova Monika
Publication year - 2018
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.13196
Subject(s) - drosha , dicer , argonaute , microrna , rna interference , biology , ribonuclease iii , rna induced silencing complex , microbiology and biotechnology , gene silencing , non coding rna , rna , biogenesis , rna silencing , rna binding protein , genetics , computational biology , gene
Micro RNA s (miRNAs) are small regulatory noncoding RNA s that are generated in the canonical RNA interference ( RNA i) pathway. Drosha, DiGeorge syndrome critical region 8 ( DGCR 8) and Dicer are key players in miRNA biogenesis. Argonaute (Ago) proteins bind to miRNAs and are guided by them to find messenger RNA targets and carry out post‐transcriptional silencing of protein‐coding genes. Recently, emerging evidence suggests that RNA i factors have a range of noncanonical functions that are beyond miRNA biogenesis. These functions pertain to various biological processes, such as development, transcriptional regulation, RNA processing and maintenance of genome integrity. Here, we review recent literature reporting miRNA‐independent, noncanonical functions of Drosha, DGCR 8, Dicer and Ago proteins and discuss the importance of these functions.