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Dependency relationships within the fission yeast polarity network
Author(s) -
Johnson Matthew,
Mulvihill Daniel P.
Publication year - 2018
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.13180
Subject(s) - cell polarity , polarity (international relations) , microbiology and biotechnology , yeast , microtubule , cell growth , cell , biology , actin , schizosaccharomyces , dependency (uml) , saccharomyces cerevisiae , chemistry , schizosaccharomyces pombe , genetics , computer science , software engineering
The ability to regulate polarised cell growth is crucial to maintain the viability of cells. Growth is modulated to facilitate essential cell functions and respond to the external environment. Failure to do so can lead to numerous developmental and disease states, including cancer. We have undertaken a detailed analysis of the regulatory interplay between molecules involved in the regulation and maintenance of polarised cell growth within fission yeast. Internally controlled live cell imaging was used to examine interactions between 10 key polarity proteins. Analysis reveals interplay between the microtubule and actin cytoskeletons, as well as multiple novel dependency pathways and feedback networks between groups of proteins. This study provides important insights into the conserved regulation of polarised cell growth within eukaryotes.