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Actin dynamics in host–pathogen interaction
Author(s) -
Stradal Theresia E. B.,
Schelhaas Mario
Publication year - 2018
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.13173
Subject(s) - exocytosis , endocytosis , microbiology and biotechnology , actin , actin cytoskeleton , actin remodeling , biology , pinocytosis , lipid bilayer fusion , motility , cytoskeleton , gtpase , wiskott–aldrich syndrome protein , cell , membrane , biochemistry
The actin cytoskeleton and Rho GTP ase signaling to actin assembly are prime targets of bacterial and viral pathogens, simply because actin is involved in all motile and membrane remodeling processes, such as phagocytosis, macropinocytosis, endocytosis, exocytosis, vesicular trafficking and membrane fusion events, motility, and last but not least, autophagy. This article aims at providing an overview of the most prominent pathogen‐induced or ‐hijacked actin structures, and an outlook on how future research might uncover additional, equally sophisticated interactions.