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IFN ‐γ enhances the wound healing effect of late EPC s ( LEPC s) via BST 2‐mediated adhesion to endothelial cells
Author(s) -
Lee Bom Nae Rin,
Chang HyunKyung,
Son Yeon Sung,
Lee Dabin,
Kwon SangMo,
Kim PyungHwan,
Cho JeYoel
Publication year - 2018
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.13078
Subject(s) - adhesion , wound healing , downregulation and upregulation , microbiology and biotechnology , chemistry , regeneration (biology) , progenitor cell , endothelial stem cell , cell adhesion , immunology , biology , in vitro , stem cell , biochemistry , organic chemistry , gene
Circulating late endothelial progenitor cells ( LEPC s) home to injured vessels, initiating blood vessel regeneration. This process requires the initial adhesion of LEPC s to endothelial cells within the wounded site. In this study, treating LEPC s with IFN ‐γ enhanced wound healing through BST 2‐mediated adhesion to endothelial cells. We found that IFN ‐γ significantly upregulated BST 2 expression in both LEPC s and EC s and increased tube formation in LEPC s. Upregulated BST 2 increased LEPC adhesion to EC s through a tight homophilic interaction of its extracellular domain. Finally, when the IFN ‐γ‐treated LEPC s were injected into the wounded mouse tail vein, superior therapeutic effects of wound closure were observed. This study provides a useful application to enhance the adhesion of LEPC s for vessel regeneration and wound closure.