Premium
Regulation of primary micro RNA processing
Author(s) -
Creugny Antoine,
Fender Aurélie,
Pfeffer Sébastien
Publication year - 2018
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.13067
Subject(s) - rna , riboswitch , biogenesis , microbiology and biotechnology , rna binding protein , biology , non coding rna , function (biology) , rna silencing , computational biology , chemistry , rna interference , genetics , gene
Micro RNA s (mi RNA s) are evolutionarily conserved small regulatory RNA s that participate in the adjustment of many, if not all, fundamental biological processes. Molecular mechanisms involved in mi RNA biogenesis and mode of action have been elucidated in the past two decades. Similar to many cellular pathways, mi RNA processing and function can be globally or specifically regulated at several levels and by numerous proteins and RNA s. Given their role as fine‐tuning molecules, it is essential for mi RNA expression to be tightly regulated in order to maintain cellular homeostasis. Here, we review our current knowledge of the first step of their maturation occurring in the nucleus and how it can be specifically and dynamically modulated.