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Utilizing DNA for functionalization of biomaterial surfaces
Author(s) -
Scharnweber Dieter,
Bierbaum Susanne,
WolfBrandstetter Cornelia
Publication year - 2018
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.13065
Subject(s) - surface modification , dna , biomaterial , nucleic acid , substrate (aquarium) , nanotechnology , chemistry , biophysics , combinatorial chemistry , materials science , biochemistry , biology , ecology
DNA sequences are widely used for gene transfer into cells including a number of substrate surface‐based supporting systems, but due to its singular structure property profile, DNA also offers multiple options for noncanonical applications. The special case of using DNA and oligodeoxyribonucleotide (ODN) structures for surface functionalization of biomedical implants is summarized here with the major focus on (a) immobilization or anchoring of nucleic acid structures on substrate surfaces, (b) incorporation of biologically active molecules (BAM) into such systems, and (c) biological characteristics of the resulting surfaces in vitro and in vivo . Sterilizations issues, important for potential clinical applications, are also considered.