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Regulation of cellular senescence via the FOXO 4‐p53 axis
Author(s) -
Bourgeois Benjamin,
Madl Tobias
Publication year - 2018
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.13057
Subject(s) - senescence , cellular senescence , microbiology and biotechnology , chemistry , biology , biochemistry , gene , phenotype
Forkhead box O ( FOXO ) and p53 proteins are transcription factors that regulate diverse signalling pathways to control cell cycle, apoptosis and metabolism. In the last decade both FOXO and p53 have been identified as key players in aging, and their misregulation is linked to numerous diseases including cancers. However, many of the underlying molecular mechanisms remain mysterious, including regulation of ageing by FOXO s and p53. Several activities appear to be shared between FOXO s and p53, including their central role in the regulation of cellular senescence. In this review, we will focus on the recent advances on the link between FOXO s and p53, with a particular focus on the FOXO 4‐p53 axis and the role of FOXO 4/p53 in cellular senescence. Moreover, we discuss potential strategies for targeting the FOXO 4‐p53 interaction to modulate cellular senescence as a drug target in treatment of aging‐related diseases and morbidity.