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Alteration in microRNA‐17‐92 dynamics accounts for differential nature of cellular proliferation
Author(s) -
Sengupta Dola,
Govindaraj Vinodhini,
Kar Sandip
Publication year - 2018
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12974
Subject(s) - microrna , e2f , cell growth , microbiology and biotechnology , cell cycle , biology , transcription factor , cell , cell type , dynamics (music) , cellular model , chemistry , cancer research , cell culture , genetics , gene , physics , acoustics
MicroRNAs associated with the mir‐17‐92 cluster are crucial regulators of the mammalian cell cycle, as they inhibit transcription factors related to the E2F family that tightly control decision‐making events for a cell to commit for active cellular proliferation. Intriguingly, in many solid cancers, these mir‐17‐92 cluster members are overexpressed, whereas in some hematopoietic cancers they are down‐regulated. Our proposed model of the Myc/E2F/mir‐17‐92 network demonstrates that the differential expression pattern of mir‐17‐92 in different cell types can be conceived due to having a contrasting E2F dynamics induced by mir‐17‐92. The model predicts that by explicitly altering the mir‐17‐92‐related part of the network, experimentally it is possible to control cellular proliferation in a cell type‐dependent manner for therapeutic intervention.