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Regulation of neuronal development and function by ROS
Author(s) -
Oswald Matthew C. W.,
Garnham Nathan,
Sweeney Sean T.,
Landgraf Matthias
Publication year - 2018
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12972
Subject(s) - context (archaeology) , reactive oxygen species , growth cone , neuroscience , microbiology and biotechnology , biology , function (biology) , neurotransmission , nervous system , ageing , receptor , biochemistry , genetics , paleontology , axon
Reactive oxygen species ( ROS ) have long been studied as destructive agents in the context of nervous system ageing, disease and degeneration. Their roles as signalling molecules under normal physiological conditions is less well understood. Recent studies have provided ample evidence of ROS ‐regulating neuronal development and function, from the establishment of neuronal polarity to growth cone pathfinding; from the regulation of connectivity and synaptic transmission to the tuning of neuronal networks. Appreciation of the varied processes that are subject to regulation by ROS might help us understand how changes in ROS metabolism and buffering could progressively impact on neuronal networks with age and disease.