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AID recruits the RNA exosome to degrade HIV ‐1 nascent transcripts through interaction with the Tat‐P‐ TEF b‐ TAR RNP complex
Author(s) -
Wang Ruixuan,
Zhang Xiaowei,
Ding Haibo,
Qiao Ying,
Han Xiaoxu,
Geng Wenqing,
Guan Gefei,
Cui Hualu,
Zhao Bin,
Wu Yuntao,
Liang Guoxin,
Shang Hong
Publication year - 2018
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12954
Subject(s) - chemistry
Activation‐induced cytidine deaminase ( AID ), a member of the APOBEC family that induces antibody diversification, has been shown to inhibit the replication of hepatitis B virus, Kaposi's sarcoma‐associated herpesvirus, and retro‐transposons. However, whether AID can inhibit human immunodeficiency virus 1 ( HIV ‐1) replication remains unclear. Here, we report that AID impairs the synthesis of HIV ‐1 components by interacting with the complex of Tat. This interaction recruits the RNA exosome to degrade the nascent HIV ‐1 transcript. AID also targets the HIV ‐1‐integrated genome via the Tat‐P‐ TEF b‐ TAR complex. Thus, we propose a novel function for AID as an adaptor protein that represses viral transcription. Our findings provide insights into developing anti‐ HIV therapeutics and understanding how host cells restrict integrated virus replication.