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The role of phospholipid molecular species in determining the physical properties of yeast membranes
Author(s) -
Renne Mike F.,
de Kroon Anton I. P. M.
Publication year - 2018
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12944
Subject(s) - glycerophospholipids , glycerophospholipid , membrane , phospholipid , eukaryote , saccharomyces cerevisiae , membrane biophysics , biochemistry , chemistry , biological membrane , function (biology) , yeast , biophysics , biology , microbiology and biotechnology , genome , gene
In most eukaryotes, including Saccharomyces cerevisiae , glycerophospholipids are the main membrane lipid constituents. Besides serving as general membrane ‘building blocks’, glycerophospholipids play an important role in determining the physical properties of the membrane, which are crucial for proper membrane function. To ensure optimal physical properties, membrane glycerophospholipid composition and synthesis are tightly regulated. This review will summarize our current knowledge of factors and processes determining the membrane glycerophospholipid composition of the reference eukaryote S. cerevisiae at the level of molecular species. Extrapolating from relevant model membrane data, we also discuss how modulation of the molecular species composition can regulate membrane physical properties.