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Identification of novel bone morphogenetic protein‐ responsive elements in a hepcidin promoter
Author(s) -
Kanamori Yohei,
Murakami Masaru,
Matsui Tohru,
Funaba Masayuki
Publication year - 2017
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12900
Subject(s) - hepcidin , bone morphogenetic protein , transcription (linguistics) , transcription factor , promoter , bone morphogenetic protein 6 , bone morphogenetic protein 2 , microbiology and biotechnology , gene , bmpr2 , biology , chemistry , gene expression , bone morphogenetic protein 7 , genetics , in vitro , immunology , inflammation , linguistics , philosophy
Hepcidin plays a central role in systemic iron metabolism. The bone morphogenetic protein (BMP) pathway regulates expression of hepcidin through transcriptional activation via BMP‐responsive elements (REs) 1 and 2 on the promoter. Previous studies also revealed that the BMP pathway stimulates transcription of its target genes via GC‐rich sequences on the promoter. A search for GC‐rich sequences on the hepcidin promoter indicated 13 regions across the distal (A to F), middle (G to I), and proximal (J to M) areas; among them, mutations of the GC‐rich element found in regions B to D exhibited decreased responsiveness to ALK3(QD) expression in the presence of BMP‐RE1 mutations, indicating necessity of the elements for full expression of hepcidin by the BMP pathway.