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Synergistic interaction of the cannabinoid and death receptor systems – a potential target for future cancer therapies?
Author(s) -
Keresztes Attila,
Streicher John M.
Publication year - 2017
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12863
Subject(s) - cannabinoid receptor , cannabinoid , receptor , cannabinoid receptor agonists , programmed cell death , apoptosis , tumor necrosis factor alpha , cannabinoid receptor type 2 , pharmacology , cancer , cancer cell , endocannabinoid system , chemistry , cancer research , biology , medicine , biochemistry , immunology , agonist
Cannabinoid receptors have been shown to interact with other receptors, including tumor necrosis factor receptor superfamily ( TNFRS ) members, to induce cancer cell death. When cannabinoids and death‐inducing ligands (including TNF‐related apoptosis‐inducing ligand) are administered together, they have been shown to synergize and demonstrate enhanced antitumor activity in vitro . Certain cannabinoid ligands have been shown to sensitize cancer cells and synergistically interact with members of the TNFRS , thus suggesting that the combination of cannabinoids with death receptor ( DR ) ligands induces additive or synergistic tumor cell death. This review summarizes recent findings on the interaction of the cannabinoid and DR systems and suggests possible clinical co‐application of cannabinoids and DR ligands in the treatment of various malignancies.