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Radial glia in the ventral telencephalon
Author(s) -
Turrero García Miguel,
Harwell Corey C.
Publication year - 2017
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12829
Subject(s) - cerebrum , neurogenesis , neuroscience , biology , embryonic stem cell , neural stem cell , progenitor cell , fate mapping , lineage (genetic) , cell lineage , progenitor , stem cell , cellular differentiation , central nervous system , microbiology and biotechnology , genetics , gene
The ventral telencephalon is the developmental origin of the basal ganglia and the source of neuronal and glial cells that integrate into developing circuits in other areas of the brain. Radial glia in the embryonic subpallium give rise to an enormous diversity of mature cell types, either directly or through other transit‐amplifying progenitors. Here, we review current knowledge about these subpallial neural stem cells and their progeny, focusing on the period of neurogenesis. We describe their cell biological features and the extrinsic and intrinsic molecular codes that guide their fate specification in defined temporal and spatial sequences. We also discuss the role of clonal lineage in the organization and specification of mature neurons.