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Multifaceted death receptor 3 signaling—promoting survival and triggering death
Author(s) -
Bittner Sebastian,
Ehrenschwender Martin
Publication year - 2017
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12747
Subject(s) - receptor , signal transduction , programmed cell death , inflammation , ligand (biochemistry) , immune system , tumor necrosis factor alpha , biology , microbiology and biotechnology , function (biology) , cancer research , immunology , apoptosis , genetics
Death Receptor 3 ( DR 3) and its cognate ligand TL 1A belong to the tumor necrosis factor superfamily ( TNFSF ). This sophisticated network of receptor–ligand systems controls innumerable biological processes. For many (if not all) TNFSF ligands and receptors, a role in conditions such as inflammation, tissue development, proliferation, and cell death has been firmly established. However, relatively little is known about DR 3 and TL 1A. Here, we review novel aspects of DR 3 signaling and DR 3‐associated signaling pathways before summarizing the function of DR 3 in the immune system. The emerging role of DR 3 in disease will be addressed before we finally critically discuss the potential therapeutic exploitation of this receptor–ligand pair.