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Early stages in the biogenesis of eukaryotic β‐barrel proteins
Author(s) -
Jores Tobias,
Rapaport Doron
Publication year - 2017
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12726
Subject(s) - organelle biogenesis , organelle , biogenesis , microbiology and biotechnology , ribosome , cytosol , biology , protein targeting , plastid , chloroplast , membrane protein , mitochondrion , bacterial outer membrane , biochemistry , membrane , rna , gene , enzyme , escherichia coli
The endosymbiotic organelles mitochondria and chloroplasts harbour, similarly to their prokaryotic progenitors, β‐barrel proteins in their outer membrane. These proteins are encoded on nuclear DNA , translated on cytosolic ribosomes and imported into their target organelles by a dedicated machinery. Recent studies have provided insights into the import into the organelles and the membrane insertion of these proteins. Although the cytosolic stages of their biogenesis are less well defined, it is speculated that upon their synthesis, chaperones prevent β‐barrel proteins from aggregation and keep them in an import‐competent conformation. In this Review, we summarize the current knowledge about the biogenesis of β‐barrel proteins, focusing on the early stages from the translation on cytosolic ribosomes to the recognition on the surface of the organelle.