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A high‐valent Fe( IV ) species is proposed to be generated from the decay of a peroxodiferric intermediate in the catalytic cycle at the di‐iron cofactor center of dioxygen‐activating enzymes such as methane monooxygenase. However, it is believed that this intermediate is not formed in the di‐iron substrate site of ferritin, where oxidation of Fe( II ) substrate to Fe(III) (the ferroxidase reaction) occurs also via a peroxodiferric intermediate. In opposition to this generally accepted view, here we present evidence for the occurrence of a high‐valent Fe( IV ) in the ferroxidase reaction of an archaeal ferritin, which is based on trapped intermediates obtained with the freeze‐quench technique and combination of spectroscopic characterization. We hypothesize that a Fe( IV ) intermediate catalyzes oxidation of excess Fe( II ) nearby the ferroxidase center.

Spectroscopic evidence for the presence of a high‐valent Fe( IV ) species in the ferroxidase reaction of an archaeal ferritin