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Hypothalamic lipid‐laden astrocytes induce microglia migration and activation
Author(s) -
Kwon YoonHee,
Kim Jiye,
Kim ChuSook,
Tu Thai Hien,
Kim MinSeon,
Suk Kyoungho,
Kim Dong Hee,
Lee Byung Ju,
Choi HyeSeon,
Park Taesun,
Choi MyungSook,
Goto Tsuyoshi,
Kawada Teruo,
Ha Tae Youl,
Yu Rina
Publication year - 2017
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12691
Subject(s) - microglia , astrogliosis , inflammation , astrocyte , tumor necrosis factor alpha , lipid metabolism , microbiology and biotechnology , neuroglia , lipid droplet , chemistry , downregulation and upregulation , proinflammatory cytokine , biology , lipid signaling , endocrinology , immunology , central nervous system , biochemistry , gene
Obesity‐induced hypothalamic inflammation is closely associated with various metabolic complications and neurodegenerative disorders. Astrocytes, the most abundant glial cells in the central nervous system, play a crucial role in pathological hypothalamic inflammatory processes. Here, we demonstrate that hypothalamic astrocytes accumulate lipid droplets under saturated fatty acid‐rich conditions, such as obese environment, and that the lipid‐laden astrocytes increase astrogliosis markers and inflammatory cytokines ( TNF α, IL ‐1β, IL ‐6, MCP ‐1) at the transcript and/or protein level. Medium conditioned by the lipid‐laden astrocytes stimulate microglial chemotactic activity and upregulate transcripts of the microglia activation marker Iba‐1 and inflammatory cytokines. These findings indicate that the lipid‐laden astrocytes formed in free fatty acid‐rich obese condition may participate in obesity‐induced hypothalamic inflammation through promoting microglia migration and activation.